انتشارات / RCMCI
تاریخ: 2019/12/01
توسط: Dr Mohammad Ali Oghabian
منتشر شده در: Iranian Journal of Pharmaceutical Research
فایل های پیوست:
URL منتشر شده: https://www.scopus.com/record/display.uri?eid=2-s2.0-85061370284&origin=resultslist

Amanlou, M., Hashemi, E., Oghabian, M.A., Ardestani, M.S.


Abstract:


Cancer detection in early stage using a powerful and noninvasive tool is of high global interest. In this experiment, a small-molecular-weight glucose based derivative of Gd 3+ -1-(4-isothiocyanatobenzyl) diethylene tri amine penta acetic acid (Gd 3+ -p-SCN-Bn-DTPA-DG) as a novel potential MR imaging contrast agents was synthesized. Gd 3+ -p-SCN-Bn-DTPA-DG was synthesized with reacting of Glucosamine and 1-(4-isothiocyanatobenzyl) diethylene triamine penta acetic acid then loaded by gadolinium to make novel agent of functional MR imaging. The relaxivity, T 1 , T 2 relaxation times, and cell toxicity of this contrast agent were studied. The results demonstrated that the sugar moieties linked to Gd 3+ -p-SCN-Bn-DTPA efficiently increase its cellular uptake in normal cells 25% and in cancereous cells upto 67%. The Gd 3+ -p-SCN-Bn-DTPA-DG significantly (p < 0.05) decreased MCF-7 tumor cell numbers without any significant toxicity on normal human kidney cells. Finally, it displayed an intense signal on T 1 weighted with respect to the unlabeled cells. Based on the findings from the present research Gd 3+ -p-SCN-Bn-DTPA-DG be a potential breast molecular imaging. However, further investigations by anticancer studies are in the pipeline. © 2019, Iranian Journal of Pharmaceutical Research. All rights reserved.