Shojaeilangari, S., Schmidtlein, C.R., Rahmim, A., Ay, M.R.
Purpose: Robust and reliable reconstruction of images from noisy and incomplete projection data holds significant potential for proliferation of cost-effective medical imaging technologies. Since conventional reconstruction techniques can generate severe artifacts in the recovered images, a notable line of research constitutes development of appropriate algorithms to compensate for missing data and to reduce noise. In the present work, we investigate the effectiveness of state-of-the-art methodologies developed for image inpainting and noise reduction to preserve the quality of reconstructed images from undersampled PET data. We aimed to assess and ascertain whether missing data recovery is best performed in the projection space prior to reconstruction or adjoined with the reconstruction step in image space.