Afsaneh Lahooti, Saeed Sarkar, Hamidreza Saligheh Rad, Amir Gholami, Sahar Nosrati, Robert N. Muller, Sophie Laurent, Cordula Grüttner, Parham Geramifar, Hassan Yousefnia, Mohammad Mazidi & Saeed Shanehsazzadeh
The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.