انتشارات / RCMCI
تاریخ: 2005/01/01
توسط: Dr Mohammad Ali Oghabian
منتشر شده در: Iranian J of Radiation Research, 3(2), 63-67
فایل های پیوست: 92620050202.pdf
URL منتشر شده: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168877/

V. Changizi, M. A. Oghabian, C. J. Hall, G Grossmann, S Wilkinson

 

Abstract:

Breast cancer is the most widespread cancer in women. Early detection of this disease has been identified as a major effective factor to save the lives of many women. The ability of small angle X-ray scattering to provide molecular in formations on live tissue has led to investigate the possibility of exploiting coherent scattered X-rays as a diagnostic tool in breast cancer. Material and Methods: In this study an angular dispersive set up was used in Daresbury laboratory (UK). 84 human breast tissue biopsies including 50 cancerous and 34 normal tissues were studied. For this study a beam size of 0.5 mm2 at the sample and a wavelength of 1.54 Å were used. The other included conditions were, the sample to detector distance (SSD), 2000 m and exposure time of 200 sec. Data were recorded using the Daresbury 2-D multiwire proportional counter operated at 512 512 pixels. The region between the specimen and detector was evacuated to minimize air scatter. With exposure to the each sample, at first a two dimensional image was produced and then the corrected intensity versus momentum transfer (Q) was plotted by using PCDetpack software. Results: It was found that there was a noticeable coherent intensity difference between tumor and normal breast tissues especially in the range of Q from 0.4-0.7 nm-1, that the coherent X-ray scattering intensity in the tumor breast tissue was significantly higher (P < 0.0001, CI= 95%) than in the normal breast tissue in the 0.4-0.7 nm –1 range. In this study, by using 2 m distance of camera collagen diffraction peaks were seen at 0.3 and 0.45 nm-1. Conclusion: Applying SAXS, it is possible to differentiate normal and tumoral breast tissues as separated

groups (P < 0.0001, CI = 95%), on the base of integrated intensity, in the 0.4-0.7 nm –1 range. Since having collagen damge in tumors, is probable therefore, it is suggested to do some cytocellular examinations on tumoral tissues.